DDR1-IN-1 dihydrochloride | Tocris Bioscience 5077/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DDR1-IN-1 dihydrochloride

catalog :

5077/10

quantity :

10 mg (also 50 mg)

price :

289 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Rauner G, Jin D, Miller D, Gierahn T, Li C, Sokol E, et al. Breast tissue regeneration is driven by cell-matrix interactions coordinating multi-lineage stem cell differentiation through DDR1. Nat Commun. 2021;12:7116 pubmed publisher
Romayor I, Badiola I, Benedicto A, Marquez J, Herrero A, Arteta B, et al. Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma. Sci Rep. 2020;10:18398 pubmed publisher
Lino M, Ngai D, Liu A, Mohabeer A, Harper C, Caruso L, et al. Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease. Mol Metab. 2020;39:101006 pubmed publisher
Vehlow A, Klapproth E, Jin S, Hannen R, Hauswald M, Bartsch J, et al. Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity. Cell Rep. 2019;26:3672-3683.e7 pubmed publisher
Mogami H, Kishore A, Word R. Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes. Sci Rep. 2018;8:696 pubmed publisher
Malaguarnera R, Nicolosi M, Sacco A, Morcavallo A, Vella V, Voci C, et al. Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. Oncotarget. 2015;6:16084-105 pubmed

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5077

SKU :

5077/10

product name :

DDR1-IN-1 dihydrochloride

Description :

Selective DDR1 inhibitor

target :

Additional RTK Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

625.51

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.

extended description :

Selective DDR1 inhibitor

chemical name text :

N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride

formula :

C 30 H 31 F 3 N 4 O 3 .2HCl

formula text :

C30H31F3N4O3.2HCl

cas num :

1780303-76-5

USD :

289 USD

product details :

Selective DDR1 inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage