SZL P1-41 | Tocris Bioscience 5076 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SZL P1-41

catalog :

5076

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Jang W, Kim T, Koo J, Kim S, Lim D. Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling. EMBO J. 2017;36:2510-2528 pubmed publisher

product information

brand :

Tocris

master code :

5076

SKU :

5076/10

product name :

SZL P1-41

description :

Selective Skp2 inhibitor; suppresses E3 ligase activity

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

420.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro . Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

catalog number base :

5076

product keywords :

SZLP1-41 Selective Skp2 inhibitors inhibits suppresses E3 ligase SCF complexes antitumor p27 Akt ubiquitination cell senescence glycolysis Ubiquitin E3 Ligases 5076, E3 Ligase

extended description :

Selective Skp2 inhibitor; suppresses E3 ligase activity

chemical name text :

3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one

formula :

C 24 H 24 N 2 O 3 S

formula text :

C24H24N2O3S

cas num :

222716-34-9

2020 USD :

218

2021 USD :

227 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage