Harmine | Tocris Bioscience 5075/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Harmine

catalog :

5075/50

quantity :

50 mg

price :

80 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Moreno R, Banerjee S, Jackson A, Quinn J, Baillie G, Dixon J, et al. The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress. Cell Death Differ. 2021;28:1563-1578 pubmed publisher
Singh S, Janjuha S, Hartmann T, Kayisoglu Ö, Konantz J, Birke S, et al. Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nat Commun. 2017;8:664 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5075

SKU :

5075/50

product name :

Harmine

Description :

Potent and selective DYRK1A inhibitor

target :

DYRK Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

212.25

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Harmine is a potent and selective inhibitor of DYRK1A (IC50 values are 80, 800 and 900 nM for DYRK1A, DYRK3 and DYRK2 respectively). Inhibits DYRK1A-mediated tau phosphorylation and regulates PPAR expression. Harmine also induces pancreatic cell proliferation and exhibits antidiabetic activity. Orally bioavailable. Harmine has high affinity (Kd = 100 nM) for the yjdF aptamer. The riboswitch function of yjdF motif RNAs is activated by Harmine and leads to robust reporter gene expressions in B. subtilis .

extended description :

Potent and selective DYRK1A inhibitor

chemical name text :

7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole

formula :

C 13 H 12 N 2 O

formula text :

C13H12N2O

cas num :

442-51-3

USD :

80 USD

product details :

Potent and selective DYRK1A inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage