PFI 3 | Tocris Bioscience 5072/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PFI 3

catalog :

5072/10

quantity :

10 mg

price :

275 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Kim B, Luo Y, Zhan X, Zhang Z, Shi X, Yi J, et al. Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation. Cell Rep. 2021;36:109357 pubmed publisher
Park S, Lee D, Seo H, Lee S, Kwon J. Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells. Sci Rep. 2020;10:16330 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5072

SKU :

5072/10

product name :

PFI 3

Description :

Potent and selective SMARCA2/4 and polybromo 1 inhibitor

target :

Bromodomain Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

321.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PFI 3 is a potent and selective polybromo 1 (PBRM1) and SMARCA4 inhibitor (Kd values are 48 and 89 nM respectively) that also inhibits SMARCA2. This compoud displays 30-fold selectivity over other sub-family branches. PFI 3 accelerates FRAP recovery in cells at a concentration of 1 M.

extended description :

Potent and selective SMARCA2/4 and polybromo 1 inhibitor

chemical name text :

(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one

formula :

C 19 H 19 N 3 O 2

formula text :

C19H19N3O2

cas num :

1819363-80-8

USD :

275 USD

product details :

Potent and selective SMARCA2/4 and polybromo 1 inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage