ITD 1 | Tocris Bioscience 5068 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ITD 1

catalog :

5068

quantity :

10 mg (also 50 mg)

price :

233 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Smyth D, Harcus Y, White M, Gregory W, Nahler J, Stephens I, et al. TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. Int J Parasitol. 2018;48:379-385 pubmed publisher

product information

brand :

Tocris

master code :

5068

SKU :

5068/10

product name :

ITD 1

description :

Selective inhibitor of TGF- signaling; induces cardiomyocyte differentiation in ESCs

target :

Compounds for Stem Cell Differentiation

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

415.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of TGF- signaling (IC50 = 0.85 M); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF- type II receptor. Inhibits TGF- -induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

catalog number base :

5068

product keywords :

ITD1 selective tgf-beta tgf-b tgf- signaling pathway inhibitors inhibits embryonic stem cells cardiogenesis cardiomyocytes TGF-beta Receptors Cardiomyocyte Stem Cells ESCs and iPSC 5068, differentiation stem cells, DIFFERENTIATION STEM CELLS

extended description :

Selective inhibitor of TGF- signaling; induces cardiomyocyte differentiation in ESCs

chemical name text :

4-[1,1 -Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester

formula :

C 27 H 29 NO 3

formula text :

C27H29NO3

cas num :

1099644-42-4

2020 USD :

224

2021 USD :

233 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage