ITD 1 | Tocris Bioscience 5068/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ITD 1

catalog :

5068/10

quantity :

10 mg (also 50 mg)

price :

289 USD

citations: 4

Reference
Rada M, Kapelanski Lamoureux A, Petrillo S, Tabari xe8 s S, SIEGEL P, Reynolds A, et al. Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases. Commun Biol. 2021;4:950 pubmed publisher
Moreno Nieves U, Tay J, Saumyaa S, Horowitz N, Shin J, Mohammad I, et al. Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Mázala D, Novak J, Hogarth M, Nearing M, Adusumalli P, Tully C, et al. TGF-β-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model. JCI Insight. 2020;5: pubmed publisher
Smyth D, Harcus Y, White M, Gregory W, Nahler J, Stephens I, et al. TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. Int J Parasitol. 2018;48:379-385 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5068

SKU :

5068/10

product name :

ITD 1

Description :

Selective inhibitor of TGF- signaling; induces cardiomyocyte differentiation in ESCs

target :

Compounds for Stem Cell Differentiation

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

415.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ITD 1 is a selective inhibitor of TGF- signaling (IC50 = 0.85 M); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF- type II receptor. Inhibits TGF- -induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

extended description :

Selective inhibitor of TGF- signaling; induces cardiomyocyte differentiation in ESCs

chemical name text :

4-[1,1 -Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester

formula :

C 27 H 29 NO 3

formula text :

C27H29NO3

cas num :

1099644-42-4

USD :

289 USD

product details :

Selective inhibitor of TGF- signaling; induces cardiomyocyte differentiation in ESCs

storage :

Store at -20°C