ICA 121431 | Tocris Bioscience 5066 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ICA 121431

catalog :

5066

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kocmálová M, Kollarik M, Canning B, Ru F, Adam Herbstsomer R, Meeker S, et al. Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves. J Pharmacol Exp Ther. 2017;361:172-180 pubmed publisher

product information

brand :

Tocris

master code :

5066

SKU :

5066/10

product name :

ICA 121431

description :

Potent and selective NaV1.3 and NaV1.1 channel blocker

target :

Voltage-gated Sodium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

449.55

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are 10 M for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.

catalog number base :

5066

product keywords :

Selective NaV blockers Sodium Channels voltage-gated voltage-dependent Na+ ICA121431 Voltage-gated Sodium Channels 5066,

extended description :

Potent and selective NaV1.3 and NaV1.1 channel blocker

chemical name text :

-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide

formula :

C 23 H 19 N 3 O 3 S 2

formula text :

C23H19N3O3S2

cas num :

313254-51-2

2020 USD :

201

2021 USD :

210 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage