ICA 121431 | Tocris Bioscience 5066/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ICA 121431

catalog :

5066/10

quantity :

10 mg (also 50 mg)

price :

265 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Espino C, Lewis C, Ortiz S, Dalal M, Garlapalli S, Wells K, et al. NaV1.1 is essential for proprioceptive signaling and motor behaviors. elife. 2022;11: pubmed publisher
Griffith T, Docter T, Lumpkin E. Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons. J Neurosci. 2019;39:7086-7101 pubmed publisher
Kocmálová M, Kollarik M, Canning B, Ru F, Adam Herbstsomer R, Meeker S, et al. Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves. J Pharmacol Exp Ther. 2017;361:172-180 pubmed publisher

image

image 1 :

Cat.No. 5066 - ICA 121431 C23H19N3O3S2 CAS No. 313254-51-2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5066

SKU :

5066/10

product name :

ICA 121431

description :

Potent and selective NaV1.3 and NaV1.1 channel blocker

target :

Voltage-gated Sodium Channel Blockers

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

449.55

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ICA 121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are 10 M for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.

product keywords :

Selective NaV blockers Sodium Channels voltage-gated voltage-dependent Na+ ICA121431 Voltage-gated Sodium Channels 5066,

extended description :

Potent and selective NaV1.3 and NaV1.1 channel blocker

chemical name text :

-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide

formula :

C23H19N3O3S2

formula text :

C23H19N3O3S2

cas num :

313254-51-2

USD :

262

USD 2025 :

265 USD

product details :

Potent and selective NaV1.3 and NaV1.1 channel blocker

more info or order :

Tocris Bioscience product webpage