Cyclotraxin B | Tocris Bioscience 5062 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cyclotraxin B

catalog :

5062

quantity :

1 mg

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Merk D, Ohli J, Merk N, Thatikonda V, Morrissy S, Schoof M, et al. Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma. Dev Cell. 2018;44:709-724.e6 pubmed publisher
Zhong P, Liu Y, Hu Y, Wang T, Zhao Y, Liu Q. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. J Neurosci. 2015;35:4469-81 pubmed publisher

product information

brand :

Tocris

master code :

5062

SKU :

5062/1

product name :

Cyclotraxin B

description :

TrkB receptor antagonist

target :

Trk Receptor Antagonists

category :

Peptides

unit size :

1 mg

observed molecular weight :

1200.36

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

catalog number base :

5062

product keywords :

anxiolytic antagonists TrkB receptors Trk Receptors 5062,

extended description :

TrkB receptor antagonist

formula :

C 48 H 73 N 13 O 17 S 3

formula text :

C48H73N13O17S3

cas num :

1203586-72-4

2020 USD :

207

2021 USD :

216 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage