RKI 1447 dihydrochloride | Tocris Bioscience 5061/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RKI 1447 dihydrochloride

catalog :

5061/10

quantity :

10 mg (also 50 mg)

price :

260 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Pepich A, T xfc mmler C, Abu Ajamieh S, Treis D, Boje A, Vellema Q, et al. The ROCK-1/2 inhibitor RKI-1447 blocks N-MYC, promotes cell death, and emerges as a synergistic partner for BET inhibitors in neuroblastoma. Cancer Lett. 2024;605:217261 pubmed publisher

product information

brand :

Tocris

catalog number base :

5061

SKU :

5061/10

product name :

RKI 1447 dihydrochloride

units size :

10 mg (also 50 mg)

description :

Potent and selective ROCK inhibitor; antitumor

target :

Rho-kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

399.29

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor (IC50 values are 6.2 and 14.5 nM for ROCK2 and ROCK1 respectively); suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Displays anti-invasive and antitumor activities in breast cancer cells. RKI 1447 dihydrochloride enhances the efficacy of BET inhibitors on the downregulation of N-Myc in vitro and in vivo .

top caption :

Potent and selective ROCK inhibitor; antitumor

extended description :

Potent and selective ROCK inhibitor; antitumor

chemical name text :

N-[(3-Hydroxyphenyl)methyl]-N -[4-(4-pyridinyl)-2-thiazolyl]urea dihydrochloride

formula :

C16H14N4O2S.2HCl

formula text :

C16H14N4O2S.2HCl

cas num :

1782109-09-4

USD :

260 USD

product details :

Potent and selective ROCK inhibitor; antitumor

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage