Ki 16425 | Tocris Bioscience 5056/5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ki 16425

catalog :

5056/5

quantity :

5 mg (also 25 mg)

price :

131 USD

citations: 2

Reference
Radhakrishnan R, Ha J, Jayaraman M, Liu J, Moxley K, Isidoro C, et al. Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts. Cancer Lett. 2018;442:464-474 pubmed publisher
Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, et al. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS ONE. 2013;8:e63718 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5056

SKU :

5056/5

product name :

Ki 16425

description :

LPA1 and LPA3 receptor antagonist

target :

Lysophosphatidic Acid (LPA) Receptor Antagonists

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

474.96

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ki 16425 is an antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 M respectively, in a GTP S binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.

product keywords :

Ki16425 lysophosphatidic acid receptors LPA1 LPA2 LPA3 YAP TAZ HIPPO Lysophosphatidic Acid Receptors Hippo/Yap signaling 5056,

extended description :

LPA1 and LPA3 receptor antagonist

chemical name text :

3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid

formula :

C23H23ClN2O5S

formula text :

C23H23ClN2O5S

cas num :

355025-24-0

USD :

129

USD 2025 :

131 USD

product details :

LPA1 and LPA3 receptor antagonist