ME 0328 | Tocris Bioscience 5054/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ME 0328

catalog :

5054/10

quantity :

10 mg (also 50 mg)

price :

180 USD

citations: 1

Reference
Wang H, Sun W. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett. 2017;385:137-143 pubmed publisher

product information

brand :

Tocris

MasterCode :

5054

SKU :

5054/10

product name :

ME 0328

unit sizes :

10 mg (also 50 mg)

description :

Selective PARP-3 inhibitor

target :

Poly(ADP-ribose) Polymerase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

321.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ME 0328 is an inhibitor of PARP-3 (IC50 = 0.89 M). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and 30 M respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.

extended description :

Selective PARP-3 inhibitor

chemical name text :

3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

formula :

C 19 H 19 N 3 O 2

formula text :

C19H19N3O2

cas num :

1445251-22-8

USD :

180 USD

product details :

Selective PARP-3 inhibitor

storage :

Store at +4°C