AC 186 | Tocris Bioscience 5053/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AC 186

catalog :

5053/10

quantity :

10 mg (also 50 mg)

price :

282 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Datta J, Willingham N, Manouchehri J, Schnell P, Sheth M, David J, et al. Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer. Front Oncol. 2022;12:857590 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5053

SKU :

5053/10

product name :

AC 186

Description :

Potent and selective ER agonist; neuroprotective

target :

Estrogen and Related Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

306.32

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AC 186 is a potent and selective ER agonist (EC50 values are 6 and 5000 nM for ER and ER respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson s disease. Decreases A levels in combination with ACP-105 in a rat model of Alzheimer s disease.

extended description :

Potent and selective ER agonist; neuroprotective

chemical name text :

4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol

formula :

C 18 H 17 F 3 O

formula text :

C18H17F3O

cas num :

1421854-16-1

USD :

282 USD

product details :

Potent and selective ER agonist; neuroprotective

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage