BIO 5192 | Tocris Bioscience 5051/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIO 5192

catalog :

5051/10

quantity :

10 mg (also 50 mg)

price :

370 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Felker S, Shrestha A, Bailey J, Pillis D, Siniard D, Malik P. Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment. JCI Insight. 2022;7: pubmed publisher
Magdaleno C, Dixon L, Rajasekaran N, Varadaraj A. HIFα independent mechanisms in renal carcinoma cells modulate divergent outcomes in fibronectin assembly mediated by hypoxia and CoCl2. Sci Rep. 2020;10:18560 pubmed publisher
Takizawa N, Okubo N, Kamo M, Chosa N, Mikami T, Suzuki K, et al. Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture. Exp Cell Res. 2017;358:411-420 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5051

SKU :

5051/10

product name :

BIO 5192

Description :

Highly potent and selective inhibitor of integrin 4 1 (VLA-4)

target :

Integrin Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

817.78

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIO 5192 is a highly selective and potent inhibitor of integrin 4 1 (Very Late Antigen-4; VLA-4) (Kd 10 pM). Selectively binds 4 1 over a range of other integrins (IC50 values are 1.8, 138, 1053, 500 and 10,000 nM for 4 1, 9 1, 2 1, 4 7 and IIb 3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.

extended description :

Highly potent and selective inhibitor of integrin 4 1 (VLA-4)

chemical name text :

(2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid

formula :

C 38 H 46 Cl 2 N 6 O 8 S

formula text :

C38H46Cl2N6O8S

cas num :

327613-57-0

USD :

370 USD

product details :

Highly potent and selective inhibitor of integrin 4 1 (VLA-4)

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage