PRT 4165 | Tocris Bioscience 5047 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PRT 4165

catalog :

5047

quantity :

10 mg (also 50 mg)

price :

87 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Chagraoui H, Kristiansen M, Ruiz J, Serra Barros A, Richter J, Hall Ponsele E, et al. SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells. Nat Commun. 2018;9:5375 pubmed publisher
Zhu S, Zhao D, Yan L, Jiang W, Kim J, Gu B, et al. BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1. Nat Commun. 2018;9:500 pubmed publisher

product information

brand :

Tocris

master code :

5047

SKU :

5047/10

product name :

PRT 4165

description :

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

235.24

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC50 = 3.9 M) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2 (Top2 ). Also shown to inhibit the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo .

catalog number base :

5047

product keywords :

PRT4165 E3 ubiquitin ligase inhibitors inhibits Bmi1 Ring1A ubiquitination ubiquitylation topoisomerase 2a Top2a Top2alpha Top2 polycomb repressive complex 1 PRC1 RNF2 Bmi1/RNF2 Ubiquitin E3 Ligases 5047, E3 Ligase

extended description :

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

chemical name text :

2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione

formula :

C 15 H 9 NO 2

formula text :

C15H9NO2

cas num :

31083-55-3

2020 USD :

2021 USD :

87 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage