PRT 4165 | Tocris Bioscience 5047/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PRT 4165

catalog :

5047/10

quantity :

10 mg (also 50 mg)

price :

111 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Hickey G, Wike C, Nie X, Guo Y, Tan M, Murphy P, et al. Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos. elife. 2022;11: pubmed publisher
Su W, Han H, Wang Y, Zhang B, Zhou B, Cheng Y, et al. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression. Cancer Cell. 2019;36:139-155.e10 pubmed publisher
Chagraoui H, Kristiansen M, Ruiz J, Serra Barros A, Richter J, Hall Ponsele E, et al. SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells. Nat Commun. 2018;9:5375 pubmed publisher
Pulikkan J, Hegde M, Ahmad H, Belaghzal H, Illendula A, Yu J, et al. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. 2018;174:172-186.e21 pubmed publisher
Zhu S, Zhao D, Yan L, Jiang W, Kim J, Gu B, et al. BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1. Nat Commun. 2018;9:500 pubmed publisher

image

image 1 :

Cat.No. 5047 - PRT 4165 C15H9NO2 CAS No. 31083-55-3

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5047

SKU :

5047/10

product name :

PRT 4165

description :

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

target :

Ubiquitin Ligase (E3) Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

235.24

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); PRT 4165 inhibits self-ubiquitination (IC50 = 3.9 M) but does not increase cellular levels of either subunit. PRT 4165 prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2 (Top2 ). PRT 4165 inhibits the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. PRT 4165 blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro .

product keywords :

PRT4165 E3 ubiquitin ligase inhibitors inhibits Bmi1 Ring1A ubiquitination ubiquitylation topoisomerase 2a Top2a Top2alpha Top2 polycomb repressive complex 1 PRC1 RNF2 Bmi1/RNF2 Ubiquitin E3 Ligases 5047, E3 Ligase

extended description :

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

chemical name text :

2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione

formula :

C15H9NO2

formula text :

C15H9NO2

cas num :

31083-55-3

USD :

109

USD 2025 :

111 USD

product details :

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

more info or order :

Tocris Bioscience product webpage