LM11A 31 dihydrochloride | Tocris Bioscience 5046/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LM11A 31 dihydrochloride

catalog :

5046/10

quantity :

10 mg (also 50 mg)

price :

148 USD

citations: 1

Reference
Plat xf3 n Corchado M, Barcelona P, Jmaeff S, Marchena M, Hern xe1 ndez Pinto A, Hern xe1 ndez S xe1 nchez C, et al. p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa. Cell Death Dis. 2017;8:e2922 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5046

SKU :

5046/10

product name :

LM11A 31 dihydrochloride

description :

Nonpeptide p75NTR ligand; neuroprotective

target :

Trk Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

95%

storage :

Desiccate at RT

observed molecular weight :

316.27

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LM11A 31 dihydrochloride is a nonpeptide p75NTR ligand and nerve growth factor (NGF) antagonist. LM11A 31 blocks p75-mediated cell death, inhibits proNGF induced cell death (IC50 = 1-10 nM), increases proliferation and survival of hippocampal neural progenitors and inhibits A -induced cell death (EC50 = 20 nM). In animal models of Alzheimer s disease LM11A 31 prevents and reverses atrophy of cholinergic neurites and reverses Alzheimer s pathology; in models of Huntington s disease LM11A 31 increases survival, reduces the formation of aggregates of mutant huntingtin and neuronal degeneration. Also promotes functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.

product keywords :

LM11A31 dihydrochloride p75NTR ligands selective NGFR nerve growth factor receptors Alzheimer's Disease neuroprotective Trk Receptors Neuronal Metabolism 5046,

extended description :

Nonpeptide p75NTR ligand; neuroprotective

chemical name text :

(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride

formula :

C12H25N3O2.2HCl

formula text :

C12H25N3O2.2HCl

cas num :

1243259-19-9

USD :

146

USD 2025 :

148 USD

product details :

Nonpeptide p75NTR ligand; neuroprotective