Nepicastat hydrochloride | Tocris Bioscience 5037/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Nepicastat hydrochloride

catalog :

5037/10

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Duarte D, Cardoso A, Vale N. Synergistic Growth Inhibition of HT-29 Colon and MCF-7 Breast Cancer Cells with Simultaneous and Sequential Combinations of Antineoplastics and CNS Drugs. Int J Mol Sci. 2021;22: pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5037

SKU :

5037/10

product name :

Nepicastat hydrochloride

Description :

Potent and selective dopamine -hydroxylase (DBH) inhibitor; orally bioavailable

target :

Hydroxylase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

331.81

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Nepicastat hydrochloride is a potent and selective dopamine -hydroxylase (DBH) inhibitor (IC50 = 9 nM) . Selective for DBH over 12 other enzymes. Decreases noradrenaline and increases dopamine levels in tissues and plasma in hypertensive rats. Prevents progressive left ventricular dysfunction in an in vivo heart failure model. Also potentiates the stimulus effects of cocaine without producing cocaine-like effects in rats. Orally bioavailable.

extended description :

Potent and selective dopamine -hydroxylase (DBH) inhibitor; orally bioavailable

chemical name text :

5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride

formula :

C 14 H 15 F 2 N 3 S.HCl

formula text :

C14H15F2N3S.HCl

cas num :

170151-24-3

USD :

195 USD

product details :

Potent and selective dopamine -hydroxylase (DBH) inhibitor; orally bioavailable

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage