CHC | Tocris Bioscience 5029/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CHC

catalog :

5029/50

quantity :

50 mg

price :

72 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Hascup E, Sime L, Peck M, Hascup K. Amyloid-β42 stimulated hippocampal lactate release is coupled to glutamate uptake. Sci Rep. 2022;12:2775 pubmed publisher
Bae S, Park P, Lee Y, Mun S, Giannopoulou E, Fujii T, et al. MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages. Cell Rep. 2021;35:109264 pubmed publisher
Babetto E, Wong K, Beirowski B. A glycolytic shift in Schwann cells supports injured axons. Nat Neurosci. 2020;: pubmed publisher
Zhang X, Liu P, Shang Y, Kerndl H, Kumstel S, Gong P, et al. Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1. J Cancer. 2020;11:479-487 pubmed publisher
Jang C, Oh S, Wada S, Rowe G, Liu L, Chan M, et al. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016;22:421-6 pubmed publisher

product information

brand :

Tocris

catalog number base :

5029

SKU :

5029/50

product name :

CHC

units size :

50 mg

description :

MCT inhibitor; decreases glycoloysis

target :

Monocarboxylate Transporter Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

189.17

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CHC is a monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo ; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.

top caption :

MCT inhibitor; decreases glycoloysis

extended description :

MCT inhibitor; decreases glycoloysis

chemical name text :

2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid

formula :

C10H7NO3

formula text :

C10H7NO3

cas num :

28166-41-8

USD :

72 USD

product details :

MCT inhibitor; decreases glycoloysis

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage