KYT 0353 | Tocris Bioscience 5026/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

KYT 0353

catalog :

5026/5

quantity :

5 mg

price :

374 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Mol Cell. 2021;: pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5026

SKU :

5026/5

product name :

KYT 0353

Description :

Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo

target :

Other Ion Pump/Transporter Inhibitors

category :

Small Molecules

unit size :

5 mg

purity :

96%

observed molecular weight :

545.24

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

KYT 0353 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1) (IC50 = 60 nM for 14C-leucine uptake in H-29 cells). Also suppreses 14C-leucine uptake in renal proximal tubule cells expressing LAT1 (IC50 = 140 nM). Displays ~500-fold selectivity for LAT1 over LAT2. Reduces cell viability and induces apoptosis in YD-38 oral cancer cells. Arrests growth in several tumor cell lines. Exhibits growth inhibitory effects on HT-29 cells in vivo .

extended description :

Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo

chemical name text :

O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride

formula :

C 23 H 19 Cl 2 N 3 O 4 .2HCl

formula text :

C23H19Cl2N3O4.2HCl

cas num :

1597402-27-1

USD :

374 USD

product details :

Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo

alt names :

JPH 203

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage