Necrosulfonamide | Tocris Bioscience 5025 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Necrosulfonamide

catalog :

5025

quantity :

10 mg (also 50 mg)

price :

108 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Chefetz I, Grimley E, Yang K, Hong L, Vinogradova E, Suciu R, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019;26:3061-3075.e6 pubmed publisher
Bagnjuk K, Stöckl J, Frohlich T, Arnold G, Behr R, Berg U, et al. Necroptosis in primate luteolysis: a role for ceramide. Cell Death Discov. 2019;5:67 pubmed publisher
Greer Y, Porat Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde V, et al. ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget. 2018;9:18454-18479 pubmed publisher
Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, et al. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 2017;20:1692-1704 pubmed publisher
Gonzalez Juarbe N, Bradley K, Shenoy A, Gilley R, Reyes L, Hinojosa C, et al. Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ. 2017;24:917-928 pubmed publisher
Heulot M, Chevalier N, Puyal J, Margue C, Michel S, Kreis S, et al. The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner. Oncotarget. 2016;7:64342-64359 pubmed publisher
Bittner S, Knoll G, Ehrenschwender M. Death receptor 3 mediates necroptotic cell death. Cell Mol Life Sci. 2017;74:543-554 pubmed publisher
GonzÃ¡lez Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015;11:e1005337 pubmed publisher

product information

brand :

Tocris

master code :

5025

SKU :

5025/10

product name :

Necrosulfonamide

description :

Necroptosis inhibitor; also inhibits pyroptosis

target :

Additional Apoptosis-related Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

461.47

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.

catalog number base :

5025

product keywords :

non-apoptotic cell death necroptosis necrosis necrosome mixed lineage kinase domain-like protein MLKL receptor interacting serine threonine kinases 3 RIP3 Gasdermin D GSDMD pyroptosis inhibitors inhibits Necroptosis Inflammasomes 5025,

extended description :

Necroptosis inhibitor; also inhibits pyroptosis

chemical name text :

(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

formula :

C 18 H 15 N 5 O 6 S 2

formula text :

C18H15N5O6S2

cas num :

1360614-48-7

2020 USD :

103

2021 USD :

108 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage