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company name :
Tocris Bioscience
product type :
chemical
product name :
Necrosulfonamide
catalog :
5025/10
quantity :
10 mg (also 50 mg)
price :
132 USD
more info or order :
citations: 19
Reference
Chauhan C, Martinez Val A, Niedenthal R, Olsen J, Kotlyarov A, Bekker Jensen S, et al. PRMT5-mediated regulatory arginine methylation of RIPK3. Cell Death Discov. 2023;9:14 pubmed publisher
Zeb S, Ye H, Liu Y, Du H, Guo Y, Zhu Y, et al. Necroptotic kinases are involved in the reduction of depression-induced astrocytes and fluoxetine's inhibitory effects on necroptotic kinases. Front Pharmacol. 2022;13:1060954 pubmed publisher
Alphonse N, Wanford J, Voak A, Gay J, Venkhaya S, Burroughs O, et al. A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling. Cell. 2022;185:2354-2369.e17 pubmed publisher
Rinkenberger N, Abrams M, Matta S, Schoggins J, Alto N, Sibley L. Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection. elife. 2021;10: pubmed publisher
Molnar T, Pallagi P, Tél B, Kiraly R, Csoma E, Jenei V, et al. Caspase-9 acts as a regulator of necroptotic cell death. FEBS J. 2021;: pubmed publisher
Najafov A, Luu H, Mookhtiar A, Mifflin L, Xia H, Amin P, et al. RIPK1 Promotes Energy Sensing by the mTORC1 Pathway. Mol Cell. 2021;81:370-385.e7 pubmed publisher
R xfc bbelke M, Fiegen D, Bauer M, Binder F, Hamilton J, King J, et al. Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc Natl Acad Sci U S A. 2020;117:33272-33281 pubmed publisher
Lee K, Lee H, Han D, Moon W, Kim K, Oh H, et al. Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer. Breast Cancer Res. 2020;22:130 pubmed publisher
Bedient L, Pokharel S, Chiok K, Mohanty I, Beach S, Miura T, et al. Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis. Viruses. 2020;12: pubmed publisher
Gonzalez Juarbe N, Riegler A, Jureka A, Gilley R, Brand J, Trombley J, et al. Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis. Cell Rep. 2020;32:108062 pubmed publisher
Chefetz I, Grimley E, Yang K, Hong L, Vinogradova E, Suciu R, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019;26:3061-3075.e6 pubmed publisher
Bagnjuk K, Stöckl J, Frohlich T, Arnold G, Behr R, Berg U, et al. Necroptosis in primate luteolysis: a role for ceramide. Cell Death Discov. 2019;5:67 pubmed publisher
Mishra S, Stephenson D, Chalfant C, Brown R. Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:158-167 pubmed publisher
Greer Y, Porat Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde V, et al. ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget. 2018;9:18454-18479 pubmed publisher
Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, et al. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 2017;20:1692-1704 pubmed publisher
Gonzalez Juarbe N, Bradley K, Shenoy A, Gilley R, Reyes L, Hinojosa C, et al. Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ. 2017;24:917-928 pubmed publisher
Heulot M, Chevalier N, Puyal J, Margue C, Michel S, Kreis S, et al. The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner. Oncotarget. 2016;7:64342-64359 pubmed publisher
Bittner S, Knoll G, Ehrenschwender M. Death receptor 3 mediates necroptotic cell death. Cell Mol Life Sci. 2017;74:543-554 pubmed publisher
González Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015;11:e1005337 pubmed publisher
product information
brand :
Tocris, a Bio-Techne Brand
catalog number base :
5025
SKU :
5025/10
product name :
Necrosulfonamide
Description :
Necroptosis inhibitor; also inhibits pyroptosis
target :
Additional Apoptosis-related Compounds
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
461.47
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Necrosulfonamide is a necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.
extended description :
Necroptosis inhibitor; also inhibits pyroptosis
chemical name text :
(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
formula :
C 18 H 15 N 5 O 6 S 2
formula text :
C18H15N5O6S2
cas num :
1360614-48-7
USD :
132 USD
product details :
Necroptosis inhibitor; also inhibits pyroptosis
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK