SF 1670 | Tocris Bioscience 5020/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SF 1670

catalog :

5020/10

quantity :

10 mg (also 50 mg)

price :

198 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Hornick E, Wallis A, Bishop G. TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22. Sci Signal. 2022;15:eabn5507 pubmed publisher
Lei W, Myers K, Rui Y, Hladyshau S, Tsygankov D, Zheng J. Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity. J Cell Biol. 2017;216:2551-2564 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5020

SKU :

5020/10

product name :

SF 1670

Description :

PTPN2 and PTEN inhibitor

target :

Protein Tyrosine Phosphatase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

307.34

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SF 1670 is a PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 M, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro . Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.

extended description :

PTPN2 and PTEN inhibitor

chemical name text :

N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide

formula :

C 19 H 17 NO 3

formula text :

C19H17NO3

cas num :

345630-40-2

USD :

198 USD

product details :

PTPN2 and PTEN inhibitor

alt names :

PTP Inhibitor XIX

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage