AC 710 | Tocris Bioscience 5013/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AC 710

catalog :

5013/10

quantity :

10 mg (also 50 mg)

price :

329 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Srinivasan A, Chang S, Zhang S, Toh W, Toh Y. Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymal stem cells via CD44 mediated PDGFR signaling. Biomaterials. 2018;167:153-167 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5013

SKU :

5013/10

product name :

AC 710

Description :

Potent and selective PDGFR family inhibitor

target :

PDGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

562.7

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AC 710 is a potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFR and CSF1R respectively; Kd = 1.3 nM for PDGFR ). Exhibits 30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.

extended description :

Potent and selective PDGFR family inhibitor

chemical name text :

N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide

formula :

C 31 H 42 N 6 O 4

formula text :

C31H42N6O4

cas num :

1351522-04-7

USD :

329 USD

product details :

Potent and selective PDGFR family inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage