BMS 509744 | Tocris Bioscience 5009 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMS 509744

catalog :

5009

quantity :

10 mg

price :

243 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Mamand S, Allchin R, Ahearne M, Wagner S. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep. 2018;8:14216 pubmed publisher

product information

brand :

Tocris

master code :

5009

SKU :

5009/10

product name :

BMS 509744

description :

Potent and selective ITK inhibitor

target :

ITK Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

623.83

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitor (IC50 = 19 nM). Displays 200-fold selectivity over Tec family kinases and 55-fold selectivity over other kinases tested. Reduces HIV infection of primary CD4+ T cells and attenuates the establishment of HIV infection in vitro . Reduces T cell proliferation and IL-2 production in vitro . Reduces lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.

catalog number base :

5009

product keywords :

BMS509744 lung inflammation allergy asthma inducible T cell kinase emt tsk HIV potent selective ITK kinase inhibitors inhibits Il2 ITK HIV 5009,

extended description :

Potent and selective ITK inhibitor

chemical name text :

N-[5-[[5-[(4-Acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]methyl]benzamide

formula :

C 32 H 41 N 5 O 4 S 2

formula text :

C32H41N5O4S2

cas num :

439575-02-7

2020 USD :

270

2021 USD :

243 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage