DR 4485 hydrochloride | Tocris Bioscience 5005/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DR 4485 hydrochloride

catalog :

5005/10

quantity :

10 mg (also 50 mg)

price :

246 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy. 2021;:1-20 pubmed publisher
Patzke C, Brockmann M, Dai J, Gan K, Grauel M, Fenske P, et al. Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell. 2019;179:498-513.e22 pubmed publisher
Chan J, McCorvy J, Acharya S, Johns M, Day T, Roth B, et al. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. PLoS Pathog. 2016;12:e1005651 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5005

SKU :

5005/10

product name :

DR 4485 hydrochloride

Description :

High affinity and selective 5-HT7 antagonist; orally bioavailable

target :

5-HT7 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

491.88

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DR 4485 hydrochloride is a high affinity and selective 5-HT7 antagonist (pKi = 8.14). Exhibits selectivity for 5-HT7 over other 5-HT receptors. Inhibits 5-HT-induced cAMP accumulation in HEK-293 cells expressing the 5-HT7 receptor. Orally bioavailable.

extended description :

High affinity and selective 5-HT7 antagonist; orally bioavailable

chemical name text :

6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one hydrochloride

formula :

C 26 H 28 Cl 2 N 2 O.HCl

formula text :

C26H28Cl2N2O.HCl

cas num :

402942-53-4

USD :

246 USD

product details :

High affinity and selective 5-HT7 antagonist; orally bioavailable

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage