Rhosin hydrochloride | Tocris Bioscience 5003/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Rhosin hydrochloride

catalog :

5003/10

quantity :

10 mg (also 50 mg)

price :

141 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Yamada S, Yassin M, Torelli F, Hansmann J, Green J, Schwarz T, et al. Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho-ROCK-mediated contractility dependent. Bioeng Transl Med. 2023;8:e10509 pubmed publisher
Ariyani W, Miyazaki W, Tsushima Y, Koibuchi N. Gadolinium-based contrast agent accelerates the migration of astrocyte via integrin αvβ3 signaling pathway. Sci Rep. 2022;12:5850 pubmed publisher
Lim Y, Cho I, Rennke H, Cho G. β2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep. 2021;11:21477 pubmed publisher
Malhi M, Norris M, Duan W, Moraes T, Maynes J. Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection. Commun Biol. 2021;4:1239 pubmed publisher
Okamoto Y, Kitakaze K, Takenouchi Y, Yamamoto S, Ishimaru H, Tsuboi K. Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation. Cell Signal. 2021;88:110156 pubmed publisher
Kim E, Jang J, Park J, Kim K, Yoon K, Yoo B, et al. Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling. Int J Mol Sci. 2020;21: pubmed publisher
Mehra A, Guérit S, Macrez R, Gosselet F, Sevin E, Lebas H, et al. Nonionotropic Action of Endothelial NMDA Receptors on Blood-Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin. J Neurosci. 2020;40:1778-1787 pubmed publisher
Zanin J, Verpeut J, Li Y, Shiflett M, Wang S, Santhakumar V, et al. The p75NTR Influences Cerebellar Circuit Development and Adult Behavior via Regulation of Cell Cycle Duration of Granule Cell Progenitors. J Neurosci. 2019;39:9119-9129 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5003

SKU :

5003/10

product name :

Rhosin hydrochloride

description :

Rho inhibitor

target :

Rho GTPase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

394.86

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Rhosin hydrochloride is a Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro . Also induces neurite outgrowth in synergy with NGF.

product keywords :

Rho GTPases inhibitors inhibits guanine nucleotide exchange factors GEF Rho 5003,

extended description :

Rho inhibitor

chemical name text :

D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride

formula :

C20H18N6O.HCl

formula text :

C20H18N6O.HCl

cas num :

1281870-42-5

USD :

135

USD 2025 :

141 USD

product details :

Rho inhibitor

more info or order :

Tocris Bioscience product webpage