INDY | Tocris Bioscience 4997/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

INDY

catalog :

4997/10

quantity :

10 mg

price :

225 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Ackeifi C, Swartz E, Kumar K, Liu H, Chalada S, Karaköse E, et al. Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors. JCI Insight. 2020;5: pubmed publisher
Wahl S, Wyatt B, Turner S, Dickinson A. Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function. BMC Genomics. 2018;19:795 pubmed publisher
Kim H, Lee K, Kim A, Choi M, Choi K, Kang M, et al. A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Dis Model Mech. 2016;9:839-48 pubmed publisher
Seu L, Sabbaj S, Duverger A, Wagner F, Anderson J, Davies E, et al. Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection. J Virol. 2015;89:6656-72 pubmed publisher
Wang P, Alvarez Perez J, Felsenfeld D, Liu H, Sivendran S, Bender A, et al. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med. 2015;21:383-8 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4997

SKU :

4997/10

product name :

INDY

Description :

DYRK1A/B inhibitor

target :

DYRK Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

235.3

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

INDY is a DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 M, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).

extended description :

DYRK1A/B inhibitor

chemical name text :

(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone

formula :

C 12 H 13 NO 2 S

formula text :

C12H13NO2S

cas num :

1169755-45-6

USD :

225 USD

product details :

DYRK1A/B inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage