K 02288 | Tocris Bioscience 4986/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

K 02288

catalog :

4986/10

quantity :

10 mg (also 50 mg)

price :

309 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ornelas I, Khandker L, Wahl S, Hashimoto H, Macklin W, Wood T. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia. 2020;68:1274-1290 pubmed publisher
Bui A, Huang M, Havard M, Laurent Tchenio F, Dautry F, Tchenio T. Transient exposure to androgens induces a remarkable self-sustained quiescent state in dispersed prostate cancer cells. Cell Cycle. 2017;16:879-893 pubmed publisher
Bui A, Laurent F, Havard M, Dautry F, Tchenio T. SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy. Cell Cycle. 2015;14:1218-31 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4986

SKU :

4986/10

product name :

K 02288

Description :

Type 1 BMP receptor inhibitor

target :

BMP and Other Activin Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

352.38

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

K 02288 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.

extended description :

Type 1 BMP receptor inhibitor

chemical name text :

3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol

formula :

C 20 H 20 N 2 O 4

formula text :

C20H20N2O4

cas num :

1431985-92-0

USD :

309 USD

product details :

Type 1 BMP receptor inhibitor

alt names :

K 02288a

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage