CRT 0066101 | Tocris Bioscience 4975/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CRT 0066101

catalog :

4975/10

quantity :

10 mg

price :

366 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Heiser D, Rubert J, Unterreiner A, Maurer C, Kamke M, Bodendorf U, et al. Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation. PLoS ONE. 2021;16:e0248668 pubmed publisher
Oueslati Morales C, Ignácz A, Bencsik N, Szíber Z, Rátkai A, Lieb W, et al. Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic. 2021;22:454-470 pubmed publisher
Veazey J, Eliseeva S, Hillman S, Stiles K, Smyth T, Morrissey C, et al. Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection. Front Immunol. 2020;11:580401 pubmed publisher
Lieb W, Lungu C, Tamas R, Berreth H, Rathert P, Storz P, et al. The GEF-H1/PKD3 signaling pathway promotes the maintenance of triple-negative breast cancer stem cells. Int J Cancer. 2020;146:3423-3434 pubmed publisher
Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214:2671-2693 pubmed publisher
Jensen D, Zhao P, Jimenez Vargas N, Lieu T, Gerges M, Yeatman H, et al. Protein Kinase D and G?? Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane. J Biol Chem. 2016;291:11285-99 pubmed publisher
Liou G, DÃ¶ppler H, Braun U, Panayiotou R, Scotti Buzhardt M, Radisky D, et al. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun. 2015;6:6200 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4975

SKU :

4975/10

product name :

CRT 0066101

Description :

Potent protein kinase D (PKD) inhibitor

target :

Protein Kinase D Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

411.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CRT 0066101 is a potent inhibitor of protein kinase D (PKD); inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). Exhibits selectivity for PKD against a panel of 90 protein kinases, including PKC , MEK, ERK, c-Raf and c-Src. Reduces proliferation and cell viability of pancreatic cancer cells expressing moderate levels of endogenous PKD1/2. Orally bioavailable.

extended description :

Potent protein kinase D (PKD) inhibitor

chemical name text :

2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride

formula :

C 18 H 22 N 6 O.2HCl

formula text :

C18H22N6O.2HCl

cas num :

1883545-60-5

USD :

366 USD

product details :

Potent protein kinase D (PKD) inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage