JIB 04 | Tocris Bioscience 4972/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JIB 04

catalog :

4972/10

quantity :

10 mg (also 50 mg)

price :

211 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Kim J, Kim J, Im S, Lee J, Hwang S, Chang E, et al. BIX01294 inhibits EGFR signaling in EGFR-mutant lung adenocarcinoma cells through a BCKDHA-mediated reduction in the EGFR level. Exp Mol Med. 2021;53:1877-1887 pubmed publisher
Song Y, Hou G, Diep J, Ooi Y, Akopyants N, Beverley S, et al. Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation. Nucleic Acids Res. 2021;49:12706-12715 pubmed publisher
Nava M, Miroshnikova Y, Biggs L, Whitefield D, Metge F, Boucas J, et al. Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell. 2020;181:800-817.e22 pubmed publisher
Kang S, Long K, Wang S, Sada A, Tumbar T. Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin. Stem Cell Reports. 2020;14:34-48 pubmed publisher
Rowbotham S, Li F, Dost A, Louie S, Marsh B, Pessina P, et al. H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression. Nat Commun. 2018;9:4559 pubmed publisher
Poulard C, Baulu E, Lee B, Pufall M, Stallcup M. Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death. Cell Death Dis. 2018;9:1038 pubmed publisher
Lee J, Kang S, Lilja K, Colletier K, Scheitz C, Zhang Y, et al. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis. Nat Commun. 2016;7:11278 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4972

SKU :

4972/10

product name :

JIB 04

Description :

Pan Jumonji inhibitor; active in vivo

target :

Histone Deacetylase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

308.76

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JIB 04 is a pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo . Prolongs survival in a mouse model of breast cancer.

extended description :

Pan Jumonji inhibitor; active in vivo

chemical name text :

5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine

formula :

C 17 H 13 ClN 4

formula text :

C17H13ClN4

cas num :

199596-05-9

USD :

211 USD

product details :

Pan Jumonji inhibitor; active in vivo

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage