PD 180970 | Tocris Bioscience 4965 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 180970

catalog :

4965

quantity :

10 mg

price :

239 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Sn S, Pandurangi J, Murumalla R, Dj V, Garimella L, Acharya A, et al. Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration. EBioMedicine. 2019;50:260-273 pubmed publisher

product information

brand :

Tocris

master code :

4965

SKU :

4965/10

product name :

PD 180970

description :

p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT

target :

Abl Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

429.27

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Potently inhibits p210bcr/abl autophosphorylation in vitro (IC50 = 5 nM). Also potently inhibits c-Src and KIT (IC50 values are 0.8 and 50 nM, respectively). Induces autophagy and reduces neuroinflammation in animal models of Parkinson's disease.

catalog number base :

4965

product keywords :

PD180970 Pfizer Bcr-Abl tyrosine kinase inhibitors inhibits c-Src KIT Abl Kinase Src Kinases Other RTKs Autophagy 4965,

extended description :

p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT

chemical name text :

6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one

formula :

C 21 H 15 Cl 2 FN 4 O

formula text :

C21H15Cl2FN4O

cas num :

287204-45-9

2020 USD :

239

2021 USD :

239 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage