SC 144 hydrochloride | Tocris Bioscience 4963 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SC 144 hydrochloride

catalog :

4963

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4963

SKU :

4963/10

product name :

SC 144 hydrochloride

description :

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

target :

Cytokine Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

358.76

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of gp130 (IC50 = 0.72 M); blocks cytokine-triggered gp130 signaling. Induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. Delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.

catalog number base :

4963

product keywords :

SC144 hydrochloride GP130 inhibitors inhibits blocks cytokine triggered gp130 signaling signalling Stat3 nuclear translocation ovarian cancer Cytokines 4963,

extended description :

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

chemical name text :

2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride

formula :

C 16 H 11 FN 6 O.HCl

formula text :

C16H11FN6O.HCl

cas num :

917497-70-2

2020 USD :

218

2021 USD :

223 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage