SB 204990 | Tocris Bioscience 4962 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 204990

catalog :

4962

quantity :

10 mg (also 50 mg)

price :

269 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, et al. Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Front Immunol. 2018;9:2858 pubmed publisher
Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, et al. Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet. 2018;50:219-228 pubmed publisher
Shah S, Carriveau W, Li J, Campbell S, Kopinski P, Lim H, et al. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. Oncotarget. 2016;7:43713-43730 pubmed publisher

product information

brand :

Tocris

master code :

4962

SKU :

4962/10

product name :

SB 204990

description :

ATP citrate lyase (ACLY) inhibitor

target :

ATP Citrate Lyase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

389.27

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATP citrate lyase (ACLY) inhibitor. Prodrug of SB 201076. Inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells. Orally active in vivo .

catalog number base :

4962

product keywords :

SB204990 ATP-citrate lyases ACL inhibitors inhibits prodrug SB-201076 cholesterol fatty acid metabolic lipids synthases transferases ACLY ATP Citrate Lyase 4962,

extended description :

ATP citrate lyase (ACLY) inhibitor

chemical name text :

(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

formula :

C 18 H 22 Cl 2 O 5

formula text :

C18H22Cl2O5

cas num :

154566-12-8

2020 USD :

258

2021 USD :

269 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage