SB 204990 | Tocris Bioscience 4962/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 204990

catalog :

4962/10

quantity :

10 mg (also 50 mg)

price :

334 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Greenwood D, Ramsey H, Nguyen P, Patterson A, Voss K, Bader J, et al. Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk. Immunohorizons. 2022;6:837-850 pubmed publisher
Lyu J, Pirooznia M, Li Y, Xiong J. The short-chain fatty acid acetate modulates epithelial-to-mesenchymal transition. Mol Biol Cell. 2022;33: pubmed publisher
Humeau J, Leduc M, Cerrato G, Loos F, Kepp O, Kroemer G. Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy. Cell Death Dis. 2020;11:433 pubmed publisher
Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, et al. Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Front Immunol. 2018;9:2858 pubmed publisher
Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, et al. Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet. 2018;50:219-228 pubmed publisher
Shah S, Carriveau W, Li J, Campbell S, Kopinski P, Lim H, et al. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. Oncotarget. 2016;7:43713-43730 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4962

SKU :

4962/10

product name :

SB 204990

Description :

ATP citrate lyase (ACLY) inhibitor

target :

ATP Citrate Lyase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

389.27

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 204990 is an ATP citrate lyase (ACLY) inhibitor; it is a prodrug of SB 201076. SB 204990 inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells. Suppresses growth of cancer cells showing aerobic glycolysis in vitro and in vivo . Orally active.

extended description :

ATP citrate lyase (ACLY) inhibitor

chemical name text :

(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

formula :

C 18 H 22 Cl 2 O 5

formula text :

C18H22Cl2O5

cas num :

154566-12-8

USD :

334 USD

product details :

ATP citrate lyase (ACLY) inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage