AR-C155858 | Tocris Bioscience 4960 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AR-C155858

catalog :

4960

quantity :

1 mg

price :

209 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Tauffenberger A, Fiumelli H, Almustafa S, Magistretti P. Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling. Cell Death Dis. 2019;10:653 pubmed publisher
Liu L, MacKenzie K, Putluri N, Maletic Savatic M, Bellen H. The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017;26:719-737.e6 pubmed publisher
Diaz Garcia C, Mongeon R, Lahmann C, Koveal D, Zucker H, Yellen G. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake. Cell Metab. 2017;26:361-374.e4 pubmed publisher
Jamali S, Klier M, Ames S, Barros L, McKenna R, Deitmer J, et al. Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function. Sci Rep. 2015;5:13605 pubmed publisher
Haas R, Smith J, Rocher Ros V, Nadkarni S, Montero Melendez T, D Acquisto F, et al. Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. PLoS Biol. 2015;13:e1002202 pubmed publisher

product information

brand :

Tocris

master code :

4960

SKU :

4960/1

product name :

AR-C155858

description :

MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells

target :

Monocarboxylate Transporter Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

461.53

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and 10 nM respectively). Exhibits no activity at MCT4. Blocks proliferation of Raji lymphoma cells in vitro . Inhibits glycolysis and glutathione synthesis in cancer cells.

catalog number base :

4960

product keywords :

monocarboxylate transporters MCT1 MCT2 inhibitors inhibits Monocarboxylate Transporters 4960,

extended description :

MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells

chemical name text :

6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

formula :

C 21 H 27 N 5 O 5 S

formula text :

C21H27N5O5S

cas num :

496791-37-8

2020 USD :

199

2021 USD :

209 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage