AR-C155858 | Tocris Bioscience 4960/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AR-C155858

catalog :

4960/1

quantity :

1 mg

price :

255 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Shaiken T, Grimm S, Siam M, Williams A, Rezaeian A, Kraushaar D, et al. Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix. iScience. 2023;26:105965 pubmed publisher
Pitmon E, Meehan E, Ahmadi E, Adler A, Wang K. High glucose promotes regulatory T cell differentiation. PLoS ONE. 2023;18:e0280916 pubmed publisher
Blaszczak W, Williams H, Swietach P. Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production. Br J Cancer. 2022;127:1365-1377 pubmed publisher
Ippolito L, Comito G, Parri M, Iozzo M, Duatti A, Virgilio F, et al. Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer. Cancer Res. 2022;82:1267-1282 pubmed publisher
Hagihara H, Shoji H, Otabi H, Toyoda A, Katoh K, Namihira M, et al. Protein lactylation induced by neural excitation. Cell Rep. 2021;37:109820 pubmed publisher
Philips T, Mironova Y, Jouroukhin Y, Chew J, Vidensky S, Farah M, et al. MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration. Cell Rep. 2021;34:108610 pubmed publisher
Babetto E, Wong K, Beirowski B. A glycolytic shift in Schwann cells supports injured axons. Nat Neurosci. 2020;: pubmed publisher
Le Douce J, Maugard M, Veran J, Matos M, J xe9 go P, Vigneron P, et al. Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease. Cell Metab. 2020;31:503-517.e8 pubmed publisher
Rossi A, Rigotto G, Valente G, Giorgio V, Basso E, Filadi R, et al. Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models. Cell Rep. 2020;30:2332-2348.e10 pubmed publisher
Ames S, Andring J, McKenna R, Becker H. CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells. Oncogene. 2020;39:1710-1723 pubmed publisher
Tauffenberger A, Fiumelli H, Almustafa S, Magistretti P. Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling. Cell Death Dis. 2019;10:653 pubmed publisher
Ippolito L, Morandi A, Taddei M, Parri M, Comito G, Iscaro A, et al. Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer. Oncogene. 2019;: pubmed publisher
Lucas S, Michel C, Marra V, Smalley J, Hennig M, Graham B, et al. Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse. J Physiol. 2018;596:1699-1721 pubmed publisher
Liu L, MacKenzie K, Putluri N, Maletic Savatic M, Bellen H. The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017;26:719-737.e6 pubmed publisher
Diaz Garcia C, Mongeon R, Lahmann C, Koveal D, Zucker H, Yellen G. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake. Cell Metab. 2017;26:361-374.e4 pubmed publisher
Rusu V, Hoch E, Mercader J, Tenen D, Gymrek M, Hartigan C, et al. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell. 2017;170:199-212.e20 pubmed publisher
Jamali S, Klier M, Ames S, Barros L, McKenna R, Deitmer J, et al. Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function. Sci Rep. 2015;5:13605 pubmed publisher
Haas R, Smith J, Rocher Ros V, Nadkarni S, Montero Melendez T, D Acquisto F, et al. Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. PLoS Biol. 2015;13:e1002202 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4960

SKU :

4960/1

product name :

AR-C155858

Description :

MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells

target :

Monocarboxylate Transporter Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

461.53

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AR-C155858 is an inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and 10 nM respectively). Exhibits no activity at MCT4. Blocks proliferation of Raji lymphoma cells in vitro . Inhibits glycolysis and glutathione synthesis in cancer cells.

extended description :

MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells

chemical name text :

6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

formula :

C 21 H 27 N 5 O 5 S

formula text :

C21H27N5O5S

cas num :

496791-37-8

USD :

255 USD

product details :

MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage