product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
CHIR 99021 trihydrochloride
catalog :
4953/10
quantity :
10 mg (also 50 mg)
price :
328 USD
more info or order :
citations: 19
Reference
Tamaoki N, Siebert S, Maeda T, Ha N, Good M, Huang Y, et al. Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells. Cell Rep Methods. 2023;3:100460 pubmed publisher
Abbott J, Tambe M, Pavlinov I, Farkhondeh A, Nguyen H, Xu M, et al. Generation and characterization of NGLY1 patient-derived midbrain organoids. Front Cell Dev Biol. 2023;11:1039182 pubmed publisher
Ateaque S, Merkouris S, Wyatt S, Allen N, Xie J, DiStefano P, et al. Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC. J Neurochem. 2022;161:463-477 pubmed publisher
Zywitza V, Rusha E, Shaposhnikov D, Ruiz Orera J, Telugu N, Rishko V, et al. Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction. Sci Rep. 2022;12:3100 pubmed publisher
Dady A, Davidson L, Halley P, Storey K. Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments. elife. 2022;11: pubmed publisher
Elorbany R, Popp J, RHODES K, Strober B, Barr K, Qi G, et al. Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation. PLoS Genet. 2022;18:e1009666 pubmed publisher
Zhu C, Wu J, Sun H, Briganti F, Meder B, Wei W, et al. Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. Nat Commun. 2021;12:4203 pubmed publisher
Truong D, Phlairaharn T, Eßwein B, Gruber C, Tümen D, Baligács E, et al. Non-invasive and high-throughput interrogation of exon-specific isoform expression. Nat Cell Biol. 2021;23:652-663 pubmed publisher
Findley A, Monziani A, Richards A, RHODES K, WARD M, Kalita C, et al. Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions. elife. 2021;10: pubmed publisher
Huang L, Desai R, Conrad D, Leite N, Akshinthala D, Lim C, et al. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. Cell Stem Cell. 2021;28:1090-1104.e6 pubmed publisher
Tao Y, Vermilyea S, Zammit M, Lu J, Olsen M, Metzger J, et al. Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. Nat Med. 2021;27:632-639 pubmed publisher
WARD M, Banovich N, Sarkar A, Stephens M, Gilad Y. Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes. elife. 2021;10: pubmed publisher
Briganti F, Sun H, Wei W, Wu J, Zhu C, Liss M, et al. iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy. Cell Rep. 2020;32:108117 pubmed publisher
Jakobi T, Siede D, Eschenbach J, Heum xfc ller A, Busch M, Nietsch R, et al. Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue. Cells. 2020;9: pubmed publisher
Selewa A, Dohn R, Eckart H, Lozano S, Xie B, Gauchat E, et al. Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation. Sci Rep. 2020;10:1535 pubmed publisher
Modic M, Grosch M, Rot G, Schirge S, Lepko T, Yamazaki T, et al. Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition. Mol Cell. 2019;74:951-965.e13 pubmed publisher
WARD M, Gilad Y. A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees. elife. 2019;8: pubmed publisher
Montefiori L, Sobreira D, Sakabe N, Aneas I, Joslin A, Hansen G, et al. A promoter interaction map for cardiovascular disease genetics. elife. 2018;7: pubmed publisher
Judson R, Quarta M, Oudhoff M, Soliman H, Yi L, Chang C, et al. Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential. Cell Stem Cell. 2018;22:177-190.e7 pubmed publisher
product information
brand :
Tocris, a Bio-Techne Brand
catalog number base :
4953
SKU :
4953/10
product name :
CHIR 99021 trihydrochloride
Description :
Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
target :
GSK-3 Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
574.72
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.
extended description :
Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
chemical name text :
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride
formula :
C 22 H 18 Cl 2 N 8 .3HCl
formula text :
C22H18Cl2N8.3HCl
cas num :
1782235-14-6
USD :
328 USD
product details :
Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
alt names :
CT99021
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK