AIM 100 | Tocris Bioscience 4946/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AIM 100

catalog :

4946/10

quantity :

10 mg (also 50 mg)

price :

266 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Gaeta A, Nourse J, Willicott K, McKay L, Keogh C, Peter K, et al. Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. PLoS Genet. 2022;18:e1010115 pubmed publisher
Verduzco D, Kuenzi B, Kinose F, Sondak V, Eroglu Z, Rix U, et al. Ceritinib Enhances the Efficacy of Trametinib in BRAF/NRAS-Wild-Type Melanoma Cell Lines. Mol Cancer Ther. 2018;17:73-83 pubmed publisher
Mahajan K, Coppola D, Rawal B, Chen Y, Lawrence H, Engelman R, et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012;287:22112-22 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4946

SKU :

4946/10

product name :

AIM 100

Description :

Potent and selective Ack1 (TNK2) inhibitor

target :

Ack1 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

371.43

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AIM 100 is a potent Ack1 (TNK2) inhibitor (IC50 = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice. Also promotes DAT endocytosis and oligomerization.

extended description :

Potent and selective Ack1 (TNK2) inhibitor

chemical name text :

5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine

formula :

C 23 H 21 N 3 O 2

formula text :

C23H21N3O2

cas num :

873305-35-2

USD :

266 USD

product details :

Potent and selective Ack1 (TNK2) inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage