ML 347 | Tocris Bioscience 4945/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 347

catalog :

4945/10

quantity :

10 mg (also 50 mg)

price :

240 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Shonibare Z, Monavarian M, O CONNELL K, Altomare D, Shelton A, Mehta S, et al. Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. Cell Rep. 2022;40:111066 pubmed publisher
Varadaraj A, Patel P, Serrao A, Bandyopadhay T, Lee N, Jazaeri A, et al. Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. Neoplasia. 2015;17:826-38 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4945

SKU :

4945/10

product name :

ML 347

Description :

Potent and selective ALK1 and ALK2 inhibitor

target :

BMP and Other Activin Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

352.39

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 347 is a potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays 200 fold selectivity over ALK3 and ALK6 and 400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).

extended description :

Potent and selective ALK1 and ALK2 inhibitor

chemical name text :

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

formula :

C 22 H 16 N 4 O

formula text :

C22H16N4O

cas num :

1062368-49-3

USD :

240 USD

product details :

Potent and selective ALK1 and ALK2 inhibitor

alt names :

LDN 193719, 1lWY, VU0469381

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage