product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Clozapine N-oxide
catalog :
4936/10
quantity :
10 mg (also 50 mg)
price :
199 USD
more info or order :
citations: 136
Reference
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product information
brand :
Tocris, a Bio-Techne Brand
catalog number base :
4936
SKU :
4936/10
product name :
Clozapine N-oxide
Description :
Activator of hM3Dq and hM4Di DREADDs
target :
DREADD Activators
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
342.82
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Clozapine N -oxide is a synthetic ligand for human muscarinic engineered receptors, designer receptors activated by designer drugs (DREADD). Binds and activates hM3Dq and hM4Di DREADDs in vitro and in vivo . Metabolite of Clozapine (Cat. No. 0444). Shown to be a P-glycoprotein (P-gp) efflux pump substrate. . Example Applications of Clozapine N -oxide (CNO): Silences hippocampal neurons expressing hM4Di DREADDs in vitro Inhibits locomotor activity of mice expressing hM3Dq in GABAergic VTA neurons Inhibits short term memory retrieval in mice expressing hM4Di in hippocampal neurons Induces heat and mechanical hypersensitivity in mice expressing hM4Di in enkephalinergic neurons in the right lumbar dorsal horn Inhibits markers of social aggression in mice expressing hM4Di in hippocampal CA2 neurons . Alternative potent and selective hM3Dq and hM4Di DREADD agonists available: Deschloroclozapine and DREADD agonist 21 . Water soluble salt also available. . This product contains 1 molar equivalent of ethanol.
extended description :
Activator of hM3Dq and hM4Di DREADDs
chemical name text :
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
formula :
C 18 H 19 ClN 4 O
formula text :
C18H19ClN4O
cas num :
34233-69-7
USD :
199 USD
product details :
Activator of hM3Dq and hM4Di DREADDs
alt names :
CNO
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK