EG 00229 | Tocris Bioscience 4931/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EG 00229

catalog :

4931/10

quantity :

10 mg

price :

259 USD

citations: 1

Reference
Nissen J, Selwood D, Tsirka S. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013;127:394-402 pubmed publisher

product information

CHEMISTRY :

O=S(C1=CC=CC2=NSN=C12)(NC3=C(C(N[C@H](C(O)=O)CCCNC(N)=N)=O)SC=C3)=O

Stock Reference :

4931/10

Cat Number :

4931

Product Name :

EG 00229

Cas Number :

[1018927-63-3]

Unit Size :

10 mg

Size :

Unit :

USD :

259 USD

Primary Category :

Enzyme-Linked Receptors

Secondary Category :

Receptor Tyrosine Kinases (RTKs)

Tertiary Category :

VEGFR

Primary Action :

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

Biological Description :

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat. No. 1097). Blocks pro-tumorigenic M2 polarization in glioma-associated microglia and macrophages and reduces tumor growth and vascularization in NSG mice.

Storage :

Store at -20°C

Formula :

C17H19N7O5S3

Molwt :

497.57

Minimum Purity :

> 98%

Solubility :

Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO

RTECS No :

Not available