CEP 1347 | Tocris Bioscience 4924/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CEP 1347

catalog :

4924/1

quantity :

1 mg

price :

357 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Cedeno Rosario L, Honda D, Sunderland A, Lewandowski M, Taylor W, Chadee D. Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division. J Biol Chem. 2022;298:102263 pubmed publisher
Singh S, Kumar S, Viswakarma N, Principe D, Das S, Sondarva G, et al. MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3. Oncogene. 2021;40:6153-6165 pubmed publisher
Kohrt S, Awadallah W, Phillips R, Case T, Jin R, Nanda J, et al. Identification of Genes Required for Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells In Vitro. Mol Cancer Ther. 2021;20:398-409 pubmed publisher
Prinz E, Aviram S, Aronheim A. WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis. Mol Biol Cell. 2018;29:2470-2480 pubmed publisher
D Amato L, Dell aversana C, Conte M, Ciotta A, Scisciola L, Carissimo A, et al. ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias. Epigenetics. 2015;10:6-18 pubmed publisher
Freedman B, Yu H, Anderson P, Roh B, Rich S, Bowden D. Genetic analysis of nitric oxide and endothelin in end-stage renal disease. Nephrol Dial Transplant. 2000;15:1794-800 pubmed

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4924

SKU :

4924/1

product name :

CEP 1347

Description :

Inhibitor of JNK signaling

target :

JNK/c-jun Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

97%

observed molecular weight :

615.76

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CEP 1347 is a potent inhibitor of mixed lineage kinases MLK3, MLK1 and MLK2 (IC50 values in vitro are 23-39 nM, 38-61 nM and 51-82 nM, respectively), and blocks downstream c-jun N-terminal kinase (JNK) activation (IC50 = 20 nM). CEP 1347 rescues motor neurons undergoing apoptosis (EC50 = 20 nM), blocks A -induced cortical neuron apoptosis (EC50 ~51 nM) and, in an animal model of Huntington s disease, restores BDNF mRNA to wild type levels. CEP 1347 is also a MDM4 inhibitor. It displays inhibition of malignant meningioma cells growth in vitro , and shows anti-tumor activity in a mouse xenograft model of meningioma in vivo . CEP 1347 is orally bioavailable and brain penetrant.

extended description :

Inhibitor of JNK signaling

chemical name text :

(9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3 ,2 ,1 -kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

formula :

C 33 H 33 N 3 O 5 S 2

formula text :

C33H33N3O5S2

cas num :

156177-65-0

USD :

357 USD

product details :

Inhibitor of JNK signaling

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage