product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Methoxy-X04
catalog :
4920
quantity :
10 mg (also 50 mg)
price :
173 USD
more info or order :
citations: 8
Reference
Socodato R, Portugal C, Canedo T, Rodrigues A, Almeida T, Henriques J, et al. Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. Cell Rep. 2020;31:107796 pubmed publisher
Zhao S, Todorov M, Cai R, Maskari R, Steinke H, Kemter E, et al. Cellular and Molecular Probing of Intact Human Organs. Cell. 2020;180:796-812.e19 pubmed publisher
Medrano Jiménez E, Jiménez Ferrer Carrillo I, Pedraza Escalona M, Ramírez Serrano C, Alvarez Arellano L, Cortés Mendoza J, et al. Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism. J Neuroinflammation. 2019;16:143 pubmed publisher
Blume T, Focke C, Peters F, Deussing M, Albert N, Lindner S, et al. Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. J Neuroinflammation. 2018;15:307 pubmed publisher
Plog B, Mestre H, Olveda G, Sweeney A, Kenney H, Cove A, et al. Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain. JCI Insight. 2018;3: pubmed publisher
Ulland T, Song W, Huang S, ULRICH J, Sergushichev A, Beatty W, et al. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. 2017;170:649-663.e13 pubmed publisher
Fu A, Hung K, Yuen M, Zhou X, Mak D, Chan I, et al. IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Proc Natl Acad Sci U S A. 2016;113:E2705-13 pubmed publisher
Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, et al. Chronic Toxoplasma gondii infection enhances ?-amyloid phagocytosis and clearance by recruited monocytes. Acta Neuropathol Commun. 2016;4:25 pubmed publisher
product information
brand :
Tocris
master code :
4920
SKU :
4920/10
product name :
Methoxy-X04
description :
Fluorescent amyloid detector; brain penetrant
target :
Fluorescent Amyloid B Probes
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
344.4
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Fluorescent amyloid (A ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar -sheet deposits. Brain penetrant.
catalog number base :
4920
product keywords :
amyloid beta fluorescent probes detection alzheimers disease brain penetrant blood brain barrier permeable high affinity amyloidbeta amyloidb amyloid Amyloid Beta Peptides Fluorescent Amyloid B Probes 4920,
extended description :
Fluorescent amyloid detector; brain penetrant
chemical name text :
4,4 -[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
formula :
C 23 H 20 O 3
formula text :
C23H20O3
cas num :
863918-78-9
2020 USD :
166
2021 USD :
173 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK