GsMTx4 | Tocris Bioscience 4912/100U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GsMTx4

catalog :

4912/100U

quantity :

100 ug

price :

440 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Allen A, Maddala R, Eldawy C, Rao P. Mechanical Load and Piezo1 Channel Regulated Myosin II Activity in Mouse Lenses. Int J Mol Sci. 2022;23: pubmed publisher
Wang S, Wang B, Shi Y, M xf6 ller T, Stegmeyer R, Strilic B, et al. Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood. 2022;140:171-183 pubmed publisher
Falleroni F, Bocchero U, Mortal S, Li Y, Ye Z, Cojoc D, et al. Mechanotransduction in hippocampal neurons operates under localized low picoNewton forces. iScience. 2022;25:103807 pubmed publisher
Vasileva V, Morachevskaya E, Sudarikova A, Negulyaev Y, Chubinskiy Nadezhdin V. Selective Chemical Activation of Piezo1 in Leukemia Cell Membrane: Single Channel Analysis. Int J Mol Sci. 2021;22: pubmed publisher
Beaulieu Laroche L, Christin M, Donoghue A, Agosti F, Yousefpour N, Petitjean H, et al. TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell. 2020;180:956-967.e17 pubmed publisher
Sun W, Chi S, Li Y, Ling S, Tan Y, Xu Y, et al. The mechanosensitive Piezo1 channel is required for bone formation. elife. 2019;8: pubmed publisher
Tsimbouri P, Childs P, Pemberton G, Yang J, Jayawarna V, Orapiriyakul W, et al. Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor. Nat Biomed Eng. 2017;1:758-770 pubmed publisher
Wong T, Juang W, Tsai C, Tseng C, Lee W, Chang S, et al. Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1. J Clin Med. 2018;7: pubmed publisher
Agbani E, Williams C, Li Y, van den Bosch M, Moore S, Mauroux A, et al. Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis. JCI Insight. 2018;3: pubmed publisher
dela Paz N, Frangos J. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun. 2018;497:220-225 pubmed publisher

image

image 1 :

Cat.No. 4912 - GsMTx4 Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2 (Disulfide bridges: 2-17, 9-23, 16-30)

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4912

SKU :

4912/100U

product name :

GsMTx4

Description :

TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels

target :

TRPC Channel Blockers

category :

Peptides

unit size :

100 ug

purity :

95%

observed molecular weight :

4095.86

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels. GsMTx4 blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells. GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response. GsMTx4 decreases the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells. GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice. GsMTx4 suppresses neurogenesis and enhances astrogenesis in human neural stem cells.

extended description :

TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels

formula :

C 185 H 273 N 49 O 45 S 6

formula text :

C185H273N49O45S6

cas num :

1209500-46-8

USD :

440 USD

product details :

TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage