GNF 5 | Tocris Bioscience 4908/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GNF 5

catalog :

4908/10

quantity :

10 mg (also 50 mg)

price :

273 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4908

SKU :

4908/10

product name :

GNF 5

Description :

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

target :

Abl Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

418.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GNF 5 is a selective, non-ATP competitive allosteric inhibitor of Bcr-Abl (IC50 = 220 nM for wild-type Abl). Binds the myristate-binding site of Abl. Acts in combination with nilotinib to inhibit T315I Bcr-Abl in vitro and in vivo . Analog of GNF 2 (Cat. No. 4399). GNF 5 decreases mitochondrial function in lung cancer cells.

extended description :

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

chemical name text :

N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

formula :

C 20 H 17 F 3 N 4 O 3

formula text :

C20H17F3N4O3

cas num :

778277-15-9

USD :

273 USD

product details :

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage