UNC 1999 | Tocris Bioscience 4904/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UNC 1999

catalog :

4904/10

quantity :

10 mg (also 50 mg)

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Chagraoui H, Kristiansen M, Ruiz J, Serra Barros A, Richter J, Hall Ponsele E, et al. SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells. Nat Commun. 2018;9:5375 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4904

SKU :

4904/10

product name :

UNC 1999

Description :

Potent and selective EZH2/EZH1 inhibitor

target :

EZH2 Inhibitor

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

569.74

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UNC 1999 is a potent and SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC50 values are 10 and 45 nM, respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro . Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable. . Negative Control also available.

extended description :

Potent and selective EZH2/EZH1 inhibitor

chemical name text :

N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide

formula :

C 33 H 43 N 7 O 2

formula text :

C33H43N7O2

cas num :

1431612-23-5

USD :

264 USD

product details :

Potent and selective EZH2/EZH1 inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage