NSC 405020 | Tocris Bioscience 4902/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NSC 405020

catalog :

4902/10

quantity :

10 mg (also 50 mg)

price :

148 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Oprescu A, Michel D, Antkowiak A, Vega E, Viaud J, Courtneidge S, et al. Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix. Sci Rep. 2022;12:6255 pubmed publisher
Kyprianou C, Christodoulou N, Hamilton R, Nahaboo W, Boomgaard D, Amadei G, et al. Basement membrane remodelling regulates mouse embryogenesis. Nature. 2020;582:253-258 pubmed publisher
Kumar S, Das A, Barai A, Sen S. MMP Secretion Rate and Inter-invadopodia Spacing Collectively Govern Cancer Invasiveness. Biophys J. 2018;114:650-662 pubmed publisher
Breznik B, Motaln H, Vittori M, Rotter A, Lah Turn x161 ek T. Mesenchymal stem cells differentially affect the invasion of distinct glioblastoma cell lines. Oncotarget. 2017;8:25482-25499 pubmed publisher
Clancy J, Sedgwick A, Rosse C, Muralidharan Chari V, Raposo G, Method M, et al. Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Nat Commun. 2015;6:6919 pubmed publisher
Remacle A, Golubkov V, Shiryaev S, Dahl R, Stebbins J, Chernov A, et al. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 2012;72:2339-49 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4902

SKU :

4902/10

product name :

NSC 405020

Description :

Histone deacetylase inhibitor

target :

Synthetic Metalloprotease Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

260.16

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NSC 405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 100 mol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo . Displays no effect on the catalytic activity of MT1-MMP or MMP-2.

extended description :

Histone deacetylase inhibitor

chemical name text :

3,4-Dichloro-N-(1-methylbutyl)benzamide

formula :

C 12 H 15 Cl 2 NO

formula text :

C12H15Cl2NO

cas num :

7/6/97

USD :

148 USD

product details :

Histone deacetylase inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage