CYM 5541 | Tocris Bioscience 4897 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CYM 5541

catalog :

4897

quantity :

10 mg (also 50 mg)

price :

182 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Matsushima Nishiwaki R, Yamada N, Fukuchi K, Kozawa O. Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS ONE. 2018;13:e0209050 pubmed publisher
O Sullivan C, Schubart A, Mir A, Dev K. The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. J Neuroinflammation. 2016;13:31 pubmed publisher
Hoffmann F, Hofereiter J, RÃ¼bsamen H, Melms J, Schwarz S, Faber H, et al. Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation. 2015;12:184 pubmed publisher

product information

brand :

Tocris

master code :

4897

SKU :

4897/10

product name :

CYM 5541

description :

Selective S1P3 receptor allosteric agonist

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

316.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 M. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

catalog number base :

4897

product keywords :

CYM5541 Selective S1P3 receptors allosteric agonists SIP Sphingosine-1-phosphate Sphingosine Sphingosine-1-phosphate Receptors 4897,

extended description :

Selective S1P3 receptor allosteric agonist

chemical name text :

N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

formula :

C 19 H 28 N 2 O 2

formula text :

C19H28N2O2

cas num :

945128-26-7

2020 USD :

175

2021 USD :

182 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage