CYM 5541 | Tocris Bioscience 4897/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CYM 5541

catalog :

4897/10

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Mischler A, Karakis V, Mahinthakumar J, Carberry C, San Miguel A, Rager J, et al. Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem. 2021;296:100386 pubmed publisher
Zhang J, Vardy E, Muise E, Wang T, Visconti R, Vadlamudi A, et al. Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein-Coupled Receptor Signaling for Fibrosis. J Pharmacol Exp Ther. 2020;375:357-366 pubmed publisher
Shahbazi M, Wang T, Tao X, Weatherbee B, Sun L, Zhan Y, et al. Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun. 2020;11:3987 pubmed publisher
Matsushima Nishiwaki R, Yamada N, Fukuchi K, Kozawa O. Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS ONE. 2018;13:e0209050 pubmed publisher
O Sullivan C, Schubart A, Mir A, Dev K. The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. J Neuroinflammation. 2016;13:31 pubmed publisher
Hoffmann F, Hofereiter J, RÃ¼bsamen H, Melms J, Schwarz S, Faber H, et al. Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation. 2015;12:184 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4897

SKU :

4897/10

product name :

CYM 5541

Description :

Selective S1P3 receptor allosteric agonist

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

316.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 M. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

extended description :

Selective S1P3 receptor allosteric agonist

chemical name text :

N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

formula :

C 19 H 28 N 2 O 2

formula text :

C19H28N2O2

cas num :

945128-26-7

USD :

227 USD

product details :

Selective S1P3 receptor allosteric agonist

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage